Regarding Pipewire, I would like to share my perspective as a user.
Setting Pulseaudio for my needs (like audio effects to boost bass and add crosfeed) required editing configuration files to fine tune hardware parameters of the audio pipeline, and it never felt quite right, with occasional glitches and crashes. Once I installed Pipewire, I was good to go with audio effects. I never had to touch any hardware controls. It just works. Amazingly, the Pulseaudio compatibility inherits this property, and every audio stream is perfect in all circumstances but CPU overload. And even then, recovery is painless. The worst I had to do was restart my game, usually the buffers clean up themselves.
Regarding the Guix idea, I need to ask a more direct question, as I see no conversation around it.
Among the people attending the event, are there developers who know stuff like “where to get the correct kernel sources” and “how to set up the phone bootloader“? The point of me going is to have direct conversations of this nature.