Addendum to my original message in this discussion thread:
@coderus,
I also did pkcon remove busybox-symlinks-bash, which automatically installs the gnu-bash RPM, right after upgrading to SFOS 4.0.1.
This may be a reason, why Patchmanager 3 (the recent pipeline artefact) on SFOS 4.0.1 works fine for some and does not for others.
Plus, I also do not use the “launcher-combined” patch.
P.S.: Another factor may be, if the primary user is nemo (or defaultuser symlinked by nemo), or if it is defaultuser: On my testing device it is nemo.