Hello,
my most promising solution for ad block is the modification of the hosts file. AdBlocking on Sailfish OS via /etc/hosts | dt.iki.fi developed a suitable solution. However for me it was still very complicated to process all the steps. Therefore I wrote a bash script that includes all steps.
just download and run the following script with root permission and after reboot ad block should work out of the box: adblock-script/adblock-script.sh at main · teertinker/adblock-script · GitHub
I hope this helps some users.